RAF Typhoon jets have operated alongside France's air force in a coordinated attack targeting an underground arms cache in Syria operated by the IS group, according to the UK's MoD.
The location, identified by intelligence, was believed to be housing weapons and explosive materials, the release indicated, and was situated in mountainous terrain just above the ancient city of Palmyra in the heart of Syria.
"Our aircraft employed laser-guided Paveway IV weapons to hit a series of approach shafts down to the site... early reports indicate the target was engaged successfully," officials stated.
There was no indication of any harm to civilians in the attack on Saturday evening and every plane involved returned to base without incident, the MoD added.
The Typhoon FGR4s were assisted by a Voyager tanker plane.
Daesh - referred to as Daesh - established jihadist rule over large swathes of Syria and Iraq prior to its 2019 collapse.
"This strike underscores the UK's leading role, and determination to operate in unison with our partners, to eradicate any re-emergence of Daesh and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the Defence Secretary remarked.
RAF aircraft have performed patrols over Syrian airspace to "deter any attempted resurgence" of Islamic State following its routing at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to the personnel of the UK armed forces participating in this operation for their skill and their courage," he commented. "They were among thousands of UK service members deployed over Christmas and New Year. This mission, to take out terrorist threats who threaten our security, demonstrates how our armed forces are ready to step up, continuously, keeping Britain secure within its borders and influential overseas."
In December, the United States armed forces executed what it termed a "major assault" targeting Islamic State objectives in the country, after an assault resulted in the deaths of two US troops and a civilian linguist in Palmyra.
The U.N. reports Daesh still boasts between 5,000 and 7,000 militants in Syria and Iraq.